Staff Directory

Dr Zoltan Rusznak Name: Dr Zoltan Rusznak
Senior Lecturer (Science)
Phone
+617 3623 7583
Organisational Area
Faculty of Health Sciences
Department
School of Behavioural and Health Sciences (QLD)
Location
Brisbane
Building 208 (1100 Nudgee Road, Banyo QLD 4014)-Level 2-Room 208.2.18
Biographical Information
I have medical degree and PhD in Medical Sciences (Physiology/Neurobiology). I also have GCHE and Cert IV TESOL.
 
Between 1990 and 2010, I worked at the Department of Physiology, University of Debrecen, Hungary. I taught Medical Physiology and had several leadership roles. My primary research area had been the central auditory pathways, signal processing ability of neurons participating in hearing, their calcium homeostasis, and the modulatory mechanisms affecting them. Further, I also published in the domains of melanoma research and cardiac electrophysiology.
 
In the period of 2010-2015, I worked as member of the Brain Structure and Function Group at Neuroscience Research Australia (NeuRA, Sydney). As one of the senior members of the lab, I worked on projects addressing changes in the cellular composition of the mouse central nervous system, the impact of ageing on neuronal and non-neuronal cell numbers, cell number changes associated with the onset and progression of an Alzheimer disease-like condition, the consequences of environmental enrichment on neuronal, non-neuronal, and proliferating cell numbers of the mouse olfactory bulb and hippocampus. I have published in the domain and spinal cord motor neuron mapping as well.
 
I have published nearly 60 research articles, and I am first or last author in 30 of them. My publications have been cited nearly 1500 times, and I have an h-index of 23. I have presented my work at national and international conferences more than a 100 times, and I have been invited speaker on 11 occasions.
 
Publications
Rusznák, Z., Henskens, W., Schofield, E., Kim, W.S., Fu, Y. (2016), &lsquoAdult neurogenesis and gliogenesis: Possible mechanisms for neurorestoration&rsquo, Experimental Neurobiology, 25(3).
 
Rusznák, Z., Kim, W.S., Hsiao, J-H., Halliday, G.M., Paxinos, G., Fu, Y. (2015), &lsquoEarly in vivo effects of the human mutant amyloid-&beta protein precursor (hA&betaPPSwInd) on the mouse olfactory bulb&rsquo, Journal of Alzheimer&rsquos Disease, 49: 443&ndash457.
 
Fu, Y., Yu, Y., Paxinos, G., Watson, C., Rusznák, Z. (2015), &lsquoAgeing-dependent changes in the cellular composition of the mouse brain and spinal cord&rsquo, Neuroscience, 290: 406&ndash420.
 
Watson, C., Sengul, G., Tanaka, I., Rusznák, Z., Tokuno, H. (2015), &lsquoThe spinal cord of the common marmoset (Callithrix jacchus)&rsquo, Neuroscience Research, 93: 164&ndash175.
 
Nagy, D., Gönczi, M., Dienes, B., Szö?r, Á., Fodor, J., Nagy, Zs., Tóth, A., Fodor, T., Bai, P., Szücs, G., Rusznák, Z., Csernoch, L. (2014), &lsquoSilencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells&rsquo, Archives of Dermatological Research, 306: 885&ndash992.
 
Fu, Y., Rusznák, Z., Kwok, J., Kim, W.S., Paxinos, G. (2014), &lsquoAge-dependent alterations of the hippocampal cell composition and proliferative potential in the hAPPSwInd-J20 mouse&rsquo, Journal of Alzheimer&rsquos Disease, 41: 1177&ndash1192.
 
Bácskai, T., Rusznák, Z., Paxinos, G., Watson, C. (2014), &lsquoMusculotopic organization of the motor neurons supplying the mouse hindlimb muscles &mdash a quantitative study using Fluoro-Gold retrograde tracing&rsquo, Brain Structure and Function, 219: 303&ndash321.
 
Rusznák, Z., Pál, B., K?szeghy, Á., Fu, Y., Szücs, G., Paxinos, G. (2013), &lsquoThe hyperpolarization-activated non-specific cation current (Ih) adjusts the membrane properties, excitability, and activity pattern of the giant cells in the rat dorsal cochlear nucleus&rsquo, European Journal of Neuroscience, 37: 876&ndash890.
 
Fu, Y., Rusznák, Z., Herculano-Houzel, S., Watson, C., Paxinos, G. (2013), &lsquoCellular composition characterizing postnatal development and maturation of the mouse brain and spinal cord&rsquo, Brain Structure and Function, 218: 1337&ndash1354.
 
Kecskes, Sz., K?szeghy, Á., Szücs, G., Rusznák, Z., Matesz, C., Birinyi, A. (2013), &lsquoThree-dimensional reconstruction and quantitative morphometric analysis of pyramidal and giant neurons of the rat dorsal cochlear nucleus&rsquo, Brain Structure and Function, 218: 1279&ndash1292.
 
Bácskai, T., Fu, Y., Sengul, G., Rusznák, Z., Paxinos, G., Watson, C. (2013), &lsquoMusculotopic organization of the motor neurons supplying forelimb and shoulder girdle muscles in the mouse&rsquo, Brain Structure and Function, 218: 221&ndash238.
 
Lontay, B., Pál, B., Serf?z?, Z., K?szeghy, Á., Szücs, G., Rusznák, Z., Erd?di, F. (2012), &lsquoProtein phosphatase-1M and Rho-kinase affect exocytosis from cortical synaptosomes and influence neurotransmission at a glutamatergic giant synapse of the rat auditory system&rsquo, Journal of Neurochemistry, 123: 84&ndash99.
 
K?szeghy, Á., Vincze, J., Rusznák, Z., Fu, Y., Paxinos, G., Csernoch, L., Szücs, G. (2012), &lsquoActivation of muscarinic receptors increases the activity of the granule neurones of the rat dorsal cochlear nucleus &mdash a calcium imaging study&rsquo, Pflügers Archiv, 463: 829&ndash844.
 
Fu, Y., Yuan, Y., Halliday, G., Rusznák, Z., Watson, C., Paxinos, G. (2011), &lsquoA cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse&rsquo, Brain Structure and Function, 217: 591&ndash612.
 
Kosztka, L., Rusznák, Z., Nagy, D., Nagy, Zs., Fodor, J., Szücs, G., Telek, A., Gönczi, M., Ruzsnavszky, O., Szentandrássy, N., Csernoch, L. (2011), &lsquoInhibition of TASK-3 (KCNK9) channel biosynthesis changes cell morphology and decreases both DNA content and mitochondrial function of melanoma cells maintained in cell culture&rsquo, Melanoma Research, 21: 308&ndash322.
 
Nagy, D., Kosztka, L., Pap, P., Nagy, Zs., Rusznák, Z., Csernoch, L., Szücs, G. (2011), &lsquoCytoplasmic Ca2+ concentration changes evoked by muscarinic cholinergic stimulation in primary and metastatic melanoma cell lines&rsquo, Melanoma Research, 21: 12&ndash23.
 
Szabó, L., Rusznák, Z., Sz?cs, G., Asztalos, L., Pál, B. (2010), &lsquoEffect of tacrolimus on the excitatory synaptic transmission between the parallel fibres and pyramidal cells in the rat dorsal cochlear nucleus&rsquo, Transplantation Proceedings, 42: 2339&ndash2343.
 
K?szeghy, Á., Pál, B., Pap, P., Pocsai, K., Nagy, Zs., Sz?cs, G., Rusznák, Z. (2009), &lsquoPurkinje-like cells of the rat cochlear nucleus: a combined functional and morphological study&rsquo, Brain Research, 1297: 57&ndash69.
 
Pál, B., K?szeghy, Á., Pap, P., Bakondi, G., Pocsai, K., Sz?cs, G., Rusznák, Z. (2009), &lsquoTargets, receptors and effects of muscarinic neuromodulation on giant neurones of the rat dorsal cochlear nucleus&rsquo, European Journal of Neuroscience, 30: 769&ndash782.
 
Pap, P., K?szeghy, Á., Sz?cs, G., Rusznák, Z. (2009), &lsquoCytoplasmic Ca2+ concentration changes evoked by cholinergic stimulation in primary astrocyte cultures prepared from the rat cochlear nucleus&rsquo, Hearing Research, 255: 73&ndash83.
 
Bakondi, G., Pór, Á., Kovács, I., Sz?cs, G., Rusznák, Z. (2009), &lsquoHCN subunit expression pattern of guinea pig spiral ganglion cells&rsquo, Neuroscience, 158: 1469&ndash1477.
 
Rusznák, Z., Sz?cs, G. (2009), &lsquoSpiral ganglion neurones: an overview of morphology, firing behaviour, ionic channels and function&rsquo, Pflügers Archiv, 457: 1303&ndash1325.
 
Bakondi, G., Pór, Á., Kovács, I., Sz?cs, G., Rusznák, Z. (2008), &lsquoVoltage-gated K+ channel (Kv) subunit expression of the guinea pig spiral ganglion cells studied in a newly developed cochlear free-floating preparation&rsquo, Brain Research, 1210: 148&ndash162.
 
Rusznák, Z., Bakondi, G., Pocsai, K., Pór, Á., Kosztka, L., Pál, B., Nagy, D., Sz?cs, G. (2008), &lsquoVoltage-gated potassium channel (Kv) subunits expressed in the rat cochlear nucleus&rsquo, Journal of Histochemistry & Cytochemistry, 56: 443&ndash465.
 
Rusznák, Z., Bakondi, G., Kosztka, L., Pocsai, K., Dienes, B., Fodor, J., Telek, A., Gönczi, M., Sz?cs, G., Csernoch, L. (2008), &lsquoMitochondrial expression of the two-pore domain TASK-3 channels in malignantly transformed and non-malignant human cells&rsquo, Virchows Archiv, 452: 415&ndash426.
 
Pocsai, K., Pál, B., Pap, P., Bakondi, G., Kosztka, L., Rusznák, Z., Sz?cs, G. (2007), &lsquoRhodamine backfilling and confocal microscopy as a tool for the unambiguous identification of neuronal cell types: a study of the neurones of the rat cochlear nucleus&rsquo, Brain Research Bulletin, 71: 529&ndash538.
 
Pocsai, K., Kosztka, L., Bakondi, G., Gönczi, M., Fodor, J., Dienes, B., Szentesi, P., Kovács, I., Feninger-Barish, R., Kopf, E., Zharhary, D., Sz?cs, G., Csernoch, L., Rusznák, Z. (2006), &lsquoMelanoma cells exhibit strong intracellular TASK-3-specific immunopositivity in both tissue sections and cell culture&rsquo, Cellular and Molecular Life Sciences, 63: 2364&ndash2376.
 
Szappanos, H., Szigeti, Gy., Pál, B., Rusznák, Z., Sz?cs, G., Rajnavölgyi, É., Balla, J., Balla, Gy., Nagy, E., Leiter, É., Pócsi, I., Hagen, S., Meyer, V., Csernoch, L. (2006), &lsquoThe antifungal protein AFP secreted by Aspergillus giganteus does not cause detrimental effects on certain mammalian cells&rsquo, Peptides, 27: 1717&ndash1725.
 
Csernoch, L., Rusznák, Z. (2006), &lsquoThe changing shape of teaching physiology: problems and prospects. A remark to Prof. Arif Siddiqui&rsquos assay&rsquo, Acta Physiologica Hungarica, 93: 97&ndash98.
 
Kecskeméti, V., Rusznák, Z., Riba, P., Pál, B., Wagner, R., Harasztosi, Cs., Nánási, P., Sz?cs, G. (2005), &lsquoNorfluoxetine and fluoxetine have equal anticonvulsive and Ca2+ channel blocking potencies&rsquo, Brain Research Bulletin, 67: 126&ndash132.
 
Pór, Á., Pocsai, K., Rusznák, Z., Sz?cs,G. (2005), &lsquoPresence and distribution of three calcium binding proteins in projection neurones of the adult rat cochlear nucleus&rsquo, Brain Research, 1039: 63&ndash74.
 
Kovács, I., Pocsai, K., Czifra, G., Sarkadi, L., Sz?cs, G., Nemes, Z., Rusznák, Z. (2005), &lsquoTASK-3 immunoreactivity shows differential distribution in the human gastrointestinal tract&rsquo, Virchows Archiv, 446: 402&ndash410.
 
Szappanos, H., Szigeti, Gy., Pál, B., Rusznák, Z., Sz?cs, G., Rajnavölgyi, É., Balla, J., Balla, Gy., Nagy, E., Leiter, É., Pócsi, I., Marx, F., Csernoch, L. (2005), &lsquoThe Penicillium chrysogenum derived antifungal peptide shows no toxic effects on mammalian cells in the intended therapeutic concentration&rsquo, N.-S. Archives of Pharmacology, 374: 122&ndash132.
 
Pál, B., Pór, Á., Pocsai, K., Sz?cs, G., Rusznák, Z. (2005), &lsquoVoltage-gated and background K+ channel subunits expressed by the bushy cells of the rat cochlear nucleus&rsquo, Hearing Research, 199: 57&ndash70.
 
Pál, B., Rusznák, Z., Harasztosi, Cs., Sz?cs, G. (2004), &lsquoDepolarisation-activated K+ currents of the bushy neurones of the rat cochlear nucleus in a thin brain slice preparation&rsquo, Acta Physiologica Hungarica, 91: 83&ndash98.
 
Rusznák, Z., Pocsai, K., Kovács, I., Pór, Á., Pál, B., Bíró, T., Sz?cs, G. (2004), &lsquoDifferential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum&rsquo, Cellular and Molecular Life Sciences, 61: 1532&ndash1542.
 
Pór, Á., Harasztosi, Cs., Rusznák, Z., Sz?cs, G. (2004), &lsquoGlutamate-induced cytoplasmic Ca2+ transients in neurones isolated from the rat dorsal cochlear nucleus&rsquo, General Physiology and Biophysics, 23: 3&ndash20.
 
Szabó, Zs., Harasztosi, Cs., Kovács, I., Sz?cs, G., Rusznák, Z., Sziklai, I. (2003), &lsquoTengerimalacból izolált I. típusú ganglion spirale neuron depolarizációja által aktivált K+ áramok jellemzése&rsquo, Fül-, Orr-, Gégegyógyászat (Otorhinolaryngologia Hungarica), 49: 114&ndash123 (in Hungarian).
 
Pál, B., Pór, Á., Sz?cs, G., Kovács, I., Rusznák, Z. (2003), &lsquoHCN channels contribute to the intrinsic activity of cochlear pyramidal cells&rsquo, Cellular and Molecular Life Sciences, 60: 2189&ndash2199.
 
Dodson, P.D., Billups, B., Rusznák, Z., Sz?cs, G., Barker, M.C., Forsythe, I.D. (2003), &lsquoPresynaptic Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion&rsquo, The Journal of Physiology, 550: 27&ndash33.
 
Magyar, J., Rusznák, Z., Harasztosi, Cs., Körtvély, Á., Pacher, P., Bányászt, T., Pankucsi, Cs., Kovács, L., Sz?cs, G., Nánási, P., Kecskeméti, V. (2003), &lsquoDifferential effects of R(-) and S(+) enantiomers of fluoxetine in mammalian neural and cardiac tissues&rsquo, International Journal of Molecular Medicine, 11: 535&ndash542.
 
Szabó, Zs., Harasztosi, Cs., Sz?cs, G., Sziklai, I., Rusznák, Z. (2003), &lsquoA detailed procedure and dissection guide for the isolation of spiral ganglion cells of the guinea pig for electrophysiological experiments&rsquo, Brain Research Protocols, 10: 139&ndash147.
 
Szabó, Zs., Harasztosi, Cs., Sziklai, I., Sz?cs, G., Rusznák, Z. (2002), &lsquoIonic currents determining the membrane characteristics of type I spiral ganglion neurons of the guinea pig&rsquo, European Journal of Neuroscience, 16: 1887&ndash1895.
 
Sz?cs, G., Rusznák, Z. (2002), &lsquoCellular regulatory mechanisms influencing the activity of the cochlear nucleus: a review&rsquo, Acta Physiologica Hungarica, 89: 375&ndash414.
 
Harasztosi, Cs., Pór, Á., Rusznák, Z., Kovács, L., Sz?cs, G. (2002), &lsquoRemoval of Ca2+ following depolarisation-evoked cytoplasmic Ca2+ transients in freshly dissociated pyramidal neurones of the rat dorsal cochlear nucleus&rsquo, Brain Research, 930: 123&ndash133.
 
Harasztosi, Cs., Rusznák, Z., Kovács, L., Sz?cs, G. (2001), &lsquoEffects of divalent cations on voltage-gated Ca2+ channels of freshly isolated pyramidal cells of the rat dorsal cochlear nucleus&rsquo, General Physiology and Biophysics, 20: 349&ndash360.
 
Rusznák, Z., Harasztosi, Cs., Stanfield, P.R., Sz?cs, G. (2001), &lsquoAn improved cell isolation technique for studying intracellular Ca2+ homeostasis in neurones of the cochlear nucleus&rsquo, Brain Research Protocols, 7: 68&ndash75.
 
Cuttle, M.F., Rusznák, Z., Wong, Y.C., Ownes, S., Forsythe I.D. (2001), Modulation of a presynaptic hyperpolarization-activated cationic current (Ih) at an excitatory synaptic terminal in the rat auditory brainstem&rsquo, The Journal of Physiology, 534: 733&ndash744.
 
Rusznák, Z., Harasztosi, Cs., Stanfield, P.R., Kovács, L., Sz?cs, G. (2000), &lsquoPotassium depolarization-induced cytoplasmic [Ca2+]i transients in freshly dissociated pyramidal neurones of the rat dorsal cochlear nucleus&rsquo, Pflügers Archiv, 440: 462&ndash466.
 
Harasztosi, Cs., Forsythe, I.D., Sz?cs, G., Stanfield, P.R., Rusznák, Z. (1999), &lsquoPossible modulatory role of voltage-gated Ca2+ currents determining the membrane properties of isolated pyramidal neurons of the rat dorsal cochlear nucleus&rsquo, Brain Research, 839: 109&ndash119.
 
Doughty, JM., Barnes-Davies, M., Rusznák, Z., Harasztosi, Cs., Forsythe, ID. (1998), &lsquoContrasting Ca2+ channel subtypes at cell bodies and synaptic terminals of rat anterio-ventral cochlear bushy neurones&rsquo, The Journal of Physiology, 512: 365&ndash376.
 
Szigeti, Gy., Rusznák, Z., Kovács, L., Papp, Z. (1998), &lsquo[Ca2+]i-activated transient membrane currents are carried mainly by Cl- in isolated atrial, ventricular and Purkinje cells of rabbit heart&rsquo, Experimental Physiology, 83: 137&ndash153.
 
Rusznák, Z., Forsythe, ID., Brew, HM., Stanfield, PR. (1997), &lsquoMembrane currents influencing action potential latency in granule neurones of the rat cochlear nucleus&rsquo, European Journal of Neuroscience, 9: 2348&ndash2358.
 
Rusznák, Z., Cseresnyés, Z., Sipos, I., Magyar, J., Kovács, L., Sz?cs, G. (1996), &lsquoCharacteristics of the ventricular transient outward potassium current in genetic rodent model of diabetes&rsquo, General Physiology and Biophysics, 15: 225&ndash238.
 
Cseresnyés, Z., Rusznák, Z., Bozsányi, A., Sz?cs, G., Kovács, L. (1995), &lsquoThree different gating models for inactivation of the Ito in ventricular myocytes of rats and mice&rsquo, General Physiology and Biophysics, 14: 259&ndash276.
 
Magyar, J., Cseresnyés, Z., Sipos, I., Rusznák, Z., Sz?cs, G., Kovács, L. (1995), &lsquoEffects of insulin on the potassium currents of rat ventricular myocytes in streptozotocin-diabetes&rsquo, General Physiology and Biophysics, 14: 191&ndash201.
 
Magyar, J., Rusznák, Z., Szentesi, P., Sz?cs, G., Kovács, L (1992), &lsquoAction potentials and potassium currents in rat ventricular muscle during experimental diabetes&rsquo, Journal of Molecular and Cellular Cardiology, 24: 841&ndash853.
Research
  • My primary research area has been the central auditory pathway, signal processing ability and calcium homeostasis of neurons participating in hearing, and the modulatory mechanisms affecting these neurons.
  • I have also been publishing in the domains of melanoma research and cardiac electrophysiology.
  • More recently, I have been working on projects addressing changes in the cellular composition of the mouse central nervous system, the impact of ageing on neuronal and non-neuronal cell numbers, cell number changes associated with the onset and progression of an Alzheimer disease-like condition, and the consequences of environmental enrichment on neuronal, non-neuronal, and proliferating cell numbers of the mouse olfactory bulb and hippocampus.
  • I have published in the domain and spinal cord motor neuron mapping as well.
Experience
I have nearly 30 years of university-level teaching experience. I have taught Physiology and Neurobiology for Medical, Dentistry, Pharmacy, and Molecular Biology (BSc and MSc) students. I have developed course curricula, authored teaching materials, and organised courses. I have mentored PhD students, examined PhD candidates, and assessed PhD theses.
 
I have had a number of education-related functions. Amongst others, I have served as education officer, secretary of the Education Committee of the Faculty of General Medicine, and advisor to the Director of the International Education Centre of the University of Debrecen. At Australian Catholic University, I am Lecturer in Charge of a number of courses. I also serve at National Team Leader, and Head of Discipline (Science).
 
Besides being an experienced university-level teacher, I am an established scientist with a career total of 59 articles published in peer-reviewed international journals. I have published mostly in the domains of neuroscience, melanoma research, and cardiac physiology. I have served as member of the Neuroscience Panel of the Hungarian Research Fund, and I am currently review editor of Frontiers in Neuroscience.
 
Professional Memberships
  • Hungarian Physiological Society
  • Hungarian Neuroscience Society
  • European Neuroscience Association
  • The Physiological Society (UK)
  • Australian Neuroscience Society
 
 

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