Staff Directory

Assoc. Prof. Valentina Lorenzetti Name: Assoc. Prof. Valentina Lorenzetti
Associate Professor
+613 9230 8088
Organisational Area
Faculty of Health Sciences
School of Behavioural and Health Sciences (VIC)
Building(215 Spring Street, Melbourne VIC 3000)-Level 5-Room5.36
Biographical Information


Training & appointments


I gained my PhD at The University of Melbourne in December 2012, on the neurobiology of cannabis use. I held Research Fellows posts at the Department of Psychiatry, The University of Melbourne (2013), and at Monash University to study the neurobiology of addiction disorders (cannabis, gambling, cocaine) (2014-2016). In 2014, I visited the D'Or Research Institute (Brazil) to run the first study using a Virtual Reality brain-computer-interface in a real-time fMRI-based neurofeedback platform, which I replicated at Monash. I was in the UK for two years (2016-2018). There, I held a Research Fellow post at University of East London with Prof Fu to map neuroimmunology mechanisms of novel treatments (mindfulness, SNRI) in depression (May-July 2016) and a Senior Lecturer post at the University of Liverpool to consolidate my research agenda in addiction neuroscience. I moved back with my family to Australia with a tenure Senior Lecturer post at Australian Catholic University (Apr 2018-current).

Scientific contribution


I am recognized as an expert in the field of addiction neurosciences. Using neuroimaging and neurocognitive methods and techniques in humans, my research has advanced the current understanding of the neurocognitive and mental health correlates of (i) cannabis and alcohol dependence (ii) other psychopathologies including depression, psychotic disorders, problem gambling and opiate addiction.

Track record


My research has resulted in 636publications to date, published in well-regarded peer reviewed neuroscientific journals including American Journal of Psychiatry (IF:14.176), Human Brain Mapping (2018, IF: 4.927), Proceedings of the National Academy of Sciences of the United States of America (2018, IF: 9.504), Lancet Psychiatry (2017, IF:15.233), JAMA Psychiatry (2016, IF:16.642) and Brain (2012, IF:10.840).

I have an H-index of 22. My work has attracted >2,000 citations, including a highly cited paper in Journal of Affective Disorders (2008, IF:3.786, >460 citations). I have attracted a total grant value of ~A$2.5M, including a NHRMC project grant (2017-2021), 3 x fellowships, and other research funding.


  1. V Lorenzetti, Y Chye, C Suo, M Walterfang, DI Lubman, M Takagi, SL Whittle, A Verdejo-Garcia,  J Cousijn, C Pantelis, M Seal, A Fornito, M Yücel, N Solowij (2019), Neuroanatomical alterations in people with high and low cannabis dependence. Australian and New Zealand Journal of Psychiatry IF: 5
  2. Y Chye, S Mackey, B Gutman, A Batalla, J Cousijn, A Dagher, J J Foxe, AE Goudriaan, R Hester, K Hutchison, AM Kaag, O Korucuoglu, CR Li, E London, V Lorenzetti, M Luijten, R Martin-Santos, R Momenan, C Orr, MP Paulus, G Pearlson, L Reneman, L Schmaal, R Sinha, N Solowij, DJ Stein, EA Stein, A Uhlmann, R van Holst, DJ Veltman, A Verdejo-Garcia, M Yücel, PM Thompson, P Conrod, H Garavan (2019) Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study. Addiction Biology IF: 5.578
  3. J Luigjes, V Lorenzetti, S de Haan, GJ Youssef, LF Fontenelle, C Murawski, Z Sjoerds, W van den Brink, D Denys, M Yücel (accepted, March 2019), Defining compulsive behavior and disentangling it from impulsive behavior and habit. Neuropsychology Review IF:4.894
  4. W Hall, E Hoch, V Lorenzetti (accepted, 3 January 2019) Cannabis use and mental health: risks and benefits. European Archives of Psychiatry and Clinical Neuroscience IF:3.617
  5. N Kakoschke, V Lorenzetti, K Caeyenberghs, A Verdejo-García (2019) Impulsivity and body fat accumulation are linked to subcortical brain volumes among adolescents and adults. Scientific Reports IF: 4.122
  6. V Lorenzetti, Y Chye, P Silva, N Solowij, C Roberts (2019) Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies.
    European Archives of Psychiatry and Clinical Neuroscience IF:3.617
  7. J Spinosa, Christiansen, P., Dickson, J. M., Lorenzetti, V., & Hardman, C. A. (2019). From Socioeconomic Disadvantage to Obesity: The Mediating Role of Psychological Distress and Emotional Eating. Obesity IF: 4.402
  8. Y Chye, C Suo, V Lorenzetti, A Batalla, J Cousijn, A Goudriaan, R Martin-Santos, S Whittle, N Solowij, M Yücel (2019) Cortical surface morphology in long-term cannabis users: A multi-site MRI study. IF:4.129
  9. A Sankar, A Melin, V Lorenzetti, P Horton, SG Costafreda, CHY Fu (accepted, 30 September 2018) A systematic review and meta-analysis of the neural correlates of psychological therapies in major depression. Psychiatric Research Neuroimaging IF: 2.42
  10. L Destree, G Youssef, D Amiett, N Solowij, V Lorenzetti, A Carter, M Yucel (accepted, 11 August 2018) Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the United States. Drugs in Context
  11.  M Yücel, E Oldenhof, S Ahmed, D Belin, J Billieux, H Bowden-Jones, A Carter, SR Chamberlain, L Clark, J Connor, M Daglish, G Dom, P Dannon, T Duka, MJ Fernandez-Serrano, M Field, I Franken, RZ Goldstein, R Gonzalez, A Goudriaan, JE Grant, M Gullo, R Hester, D Hodgins, B Le Foll, RSC Lee, A Lingford-Hughes, V Lorenzetti, SJ Moeller, MR Munafò, B Odlaug, MN Potenza, R Segrave, Z Sjoerds, N Solowij, U Vaidyanathan, W van den Brink, RJ Van Holst, V Voon, R Wiers, LF Fontenelle, A Verdejo-Garcia (accepted, 14 August 2018) A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study. Addiction IF: 5.953
  12. S Mackey, ENIGMA Addiction Working Group (inc. V Lorenzetti), H Garavan (accepted, July 2018) Mega-analysis of grey matter volume in substance dependence: general and substance-specific effects. The American Journal of Psychiatry IF:13.391
  13. Y Chye, V Lorenzetti, C Suo, A Batalla, J Cousijn, AE Goudriaan, M Jenkinson, R Martin-Santos, S Whittle, M Yücel, N Solowij (2018) Alteration to hippocampal volume and shape confined to cannabis dependence: A multisite study. Addiction Biology IF: 5.578
  14. V Lorenzetti*, B Melo*, R Basilio, C Suo, M Yucel,CJ Tierra-Criollo, J Moll (accepted, 14 May 2018). Emotion regulation using virtual environments and real-time fMRI neurofeedback. Frontiers in Neurology - Applied Neuroimaging IF: 3.508
  15. S Oldham, C Murawski, G Youssef, A Fornito, M Yucel, V Lorenzetti (accepted, 10 April 2018) The anticipation and outcome phases of reward and loss processing: A neuroimaging meta?analysis of the monetary incentive delay task. Human Brain Mapping IF: 5.969
  16. XZ Kong, SR Mathias, T Guadalupe, ENIGMA Laterality Working Group, DC Glahn, B Franke, F Crivello, N Tzourio-Mazoyer, SE Fisher, PM Thompson, C Francks (accepted, 10 April 2018) Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium. Proceedings of the National Academy of Sciences of the United States of America IF: 9.504
  17. L Den Ouden, C SuoA Kandola, J Hendrikse, R Costa, M Watt, V Lorenzetti, Yücel M (accepted, February 2018 The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis. Brain Plasticity
  18. V Lorenzetti*, A Batalla*, M Yücel, C Soriano-Mas, S Bhattacharyya, M Torrens, JA Crippa, R Martin-Santos (2018) The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users. Cannabis and cannabinoid research
  19. L Prochazkova, L Parkes, A Dawson, G Youssef, G Ferreira, V Lorenzetti, R Segrave, LF Fontenelle, M Yücel (2018) Unpacking the role of self-reported compulsivity and impulsivity in obsessive-compulsive disorder. CNS Spectrums IF: 3.504, Citations: 2
  20. LM Ahveninen, JC Stout, N Georgiou-Karistianis, V Lorenzetti, Y Glikmann-Johnston (2018). Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: the IMAGE-HD study. NeuroImage: Clinical18, 881-887. 10.1016/j.nicl.2018.03.027 IF: 2.16
  21. Y Chye, N Solowij, EP Ganella, C Suoa, M Yücel, A Batalla, J Cousijn, AE Goudriaan, R Martin-Santos, S Whittle, CF Bartholomeusz*, V Lorenzetti* Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms (2017) Progress in Neuropsychopharmacology & Biological Psychiatry IF: 4.185, Citations: 3
  22. L Koenders, V Lorenzetti, C Suo, WAM Vingerhoets, W van den Brink, RW Wiers, CJ Meijer, AE Goudriaan, M Yücel, L de Haan, J Cousijn (2017) Longitudinal study of Hippocampal volumes in cannabis users. Journal of Psychopharmacology IF: 4.738, Citations: 1
  23. YY Chye, C Suo, M Yücel, L den Ouden, N Solowij,* V Lorenzetti* (2017) Cannabis-related hippocampal volumetric abnormalities specific to subregions in dependent users Psychopharmacology IF: 3.222, Citations: 3
  24. YY Chye, N Solowij, C Suo, A Batalla, J Cousijn, AE Goudriaan, R Martin-Santos, S Whittle, M Yücel,* V Lorenzetti* (2017) Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users Psychopharmacology IF: 3.222, Citations: 6
  25. K Guo, GJ Youssef, A Dawson, L Parkes, S Oostermeijer, C López-Solà, V Lorenzetti, C Greenwood, LF Fontenelle, M Yücel (2017) A psychometric validation study of the Impulsive-Compulsive behaviours Checklist: A transdiagnostic tool for addictive and compulsive behaviours. Addictive Behaviors IF: 2.686, Citations: 1
  26. M Yücel, A Carter, A Allen, B Balliene, L Clark, N Dowling, S Gainsbury, A Goudriaan, J Grant, S Hayes, D Hodgins, R van Holst, R Lattimore, C Livingstone, V Lorenzetti, DI Lubman, C Murawski, L Parkes, N Petry, R Room, B Singh, A Thomas, P Townsend, G Youssef, W Hall (2017) An interdisciplinary dialogue on gambling: Perspectives on the role for neuroscience in gambling policy and treatment. Lancet Psychiatry IF: 15.233, Citations: 4
  27. V Lorenzetti, S Alonso-Lana, G Youssef, C Suo, J Cousijn, M Takagi, N Solowij, M Yücel (Invited, 2016), Brain functional alterations is adolescent cannabis users: A systematic review of the literature. Current Pharmaceutical Design IF: 2.757, Citations: 253 doi: 10.2174/1381612822666160805155922.
  28. T Takahashi, Y Nishikawa, M Yücel, S Whittle, V Lorenzetti, M Walterfang, M Suzuki, C Pantelis, NB Allen (2016) Olfactory sulcus morphology in patients with current and past major depression Psychiatry Research Neuroimaging IF:2.455, Citations:7
  29. D Jakabek, M Yücel, V Lorenzetti, N Solowij (2016) An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age. Psychopharmacology IF: 3.222, Citations: 7
  30. N Solowji, V Lorenzetti, M Yücel (2016), The effects of cannabis use on human behavior: a call for standardization of cannabis use metrics, JAMA Psychiatry. IF: 16.642, Citations: 8
  31. LF Fontenelle, V Lorenzetti, G Murales, I Melca, M Yucel (2016) Investigating the role of anticipatory reward and habit strength in obsessive-compulsive disorder. CNS Spectrums. 10.1017/S1092852916000535 IF: 3.504, Citations: 2
  32. V Lorenzetti, J Cousijn, N Solowij, H Garavan, C Suo, M Yücel, A Verdejo-Garcia (2016), The neurobiology of cannabis use disorders: A call for evidence. Frontiers in Behavioral Neuroscience. IF: 3.138, Citations: 7
  33. V Lorenzetti, N Solowij, M Yücel (2016) The role of cannabinoids on brain structural alterations in cannabis users, Biological Psychiatry. IF: 11.982, Citations: 60
  34. V Lorenzetti*, A Batalla*, J Cousijn (2016), Cannabis use disorders and brain morphology: What do we know? Current Addiction Reports: 3(2):189-198 Citations:4
  35. V Lorenzetti*, M Yücel*, C Suo, A Zalesky, A Fornito, MJ Takagi, DI Lubman, N Solowij* (November 2015), Hippocampal harms, protection and recovery following regular cannabis use, Translational Psychiatry IF:4.691, Citations:35
  36. S Mackey, K Kan, B Chaarani, N Alia-Klein, A Batalla, S Brooks, J Cousijn, A Dagher, M De Ruiter, S Desrivieres, S Feldstein-Ewing, RZ Goldstein, A Goudriaan, MM Heitzeg, K Hutchison, CR Li, E London, V Lorenzetti, M Luijten, R Martin-Santos, A Morales, M Paulus, T Paus, G Pearlson, R Schluter, L Schmaal, G Schumann, Z Sjoerds, D Stein, EE Stein, R Sinha, N Solowij, S Tapert, A Uhlmann, D Veltman, R van Holst, H Walter, MJ Wright, M Yucel, D Yurgelun-Todd, DP Hibar, N Jahanshad, PM Thompson, DC Glahn, H Garavan, P Conrod (2015) Genetic Imaging Consortium: From neuroimaging to genes. Progress in Brain Research. IF:3.174, Citations:10
  37. M Takagi, G Youssef, V Lorenzetti (2015) Neuroimaging of the Human Brain in Adolescent Substance Users. In D De Micheli, AL Monezi Andrade, EA da Silva, MLO de Souza-Formigoni (Eds.), Drug Abuse in Adolescence. Springer International Publishing, Switzerland. Citations:1
  38. L Fontenelle, S Oostermeijer, G Mourão Ferreira, V Lorenzetti, J Luigjes, M Yücel (2015), Anticipated reward in Obsessive-Compulsive Disorder: are compulsions rewarding? The Journal of Clinical Psychiatry76(9):e1134&ndashe1135 IF: 4.247, Citations:7
  39. V Lorenzetti, J Cousijn (2015), Cannabis use disorders and brain morphology. In V R Preedy (Eds.), Neuropathology of drug addictions and substance misuse Volume 1: Common substances of abuse - tobacco, alcohol, cannabinoids and opioids. London, UK: Elsevier Inc. Citations:4
  40. P Klauser, A Fornito, V Lorenzetti, CG Davey, D Dwyer, NB Allen, M Yücel (2015), Cortico-limbic network abnormalities in individuals with current and past major depressive disorder. Journal of Affective Disorders. IF: 3.786, Citations: 10
  41. V Lorenzetti, N Solowij, SL Whittle, A Fornito, DI Lubman, C Pantelis, Murat Yücel (2015), Gross morphological brain changes with chronic, heavy cannabis use. The British Journal of Psychiatry. IF: 5.867, Citations:47
  42. N Solowij, A Zalesky, V Lorenzetti, M Yücel (2014), Chronic cannabis use and axonal fibre connectivity. Preedy VR (Ed.) The Comprehensive Handbook of Cannabis Related Pathologies, Elsevier. Citations:1
  43. M Takagi, G Youssef, V Lorenzetti (2014), Neuroimaging of the human brain and drug addicted adolescents. Neuroscience of Drug Abuse During Adolescence, What we Know?.
  44. Y Masaoka, IH Harding, N Koiwa, M Yoshida, BJ Harrison, V Lorenzetti, M Ida, M Izumizaki, C Pantelis, I Homma (2014) The neural cascade of olfactory processing: A combined fMRI-EEG study. Respiratory Physiology and Neurobiology. 204: 71-77 IF: 1.792, Citations:7
  45. V Lorenzetti, DI Lubman, A Fornito, S Whittle S, MJ Takagi, N Solowij and M Yücel (2014), The Impact of Regular Cannabis Use on the Human Brain: A Review of Structural Neuroimaging Studies. Biological Research on Addiction. Citations:2
  46. V Lorenzetti, N Solowij, A Fornito, DI Lubman, M Yücel (2014), The association between regular cannabis exposure and alterations of human brain morphology: An updated review of the literature. Current Pharmaceutical design, special issue on Neurobiological and Neurocognitive Basis of The Effects of Cannabinoids In Animals and Man: Therapeutic Potential of Cannabinoids In Psychiatry 20:2138-67. IF: 2.757, Citations: 62
  47. D Stjepanovi?, V Lorenzetti, M Yücel, Z Hawi, MA Bellgrove (2013) Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes. Translational Psychiatry. IF: 4.691, Citations: 8
  48. N Solowij, M Walterfang, DI Lubman, S Whittle, V Lorenzetti, M Styner, D Velakoulis, C Pantelis, M Yücel (2012) Alteration to hippocampal shape in cannabis users with and without schizophrenia. Schizophrenia Research. IF: 3.958, Citations: 37
  49. A Zalesky, N Solowij, M Yücel, DI Lubman, M Takagi, IH Harding, V Lorenzetti, R Wang, K Searle, C Pantelis, M Seal (2012), Effect of Long-Term Cannabis Use on Axonal Fiber Connectivity. Brain, 135: 2245-2255. IF: 10.840, Citations: 215
  50. Harding, N Solowij, BJ Harrison, M Takagi, V Lorenzetti, DI Lubman, ML Seal, C Pantelis, M Yücel (2012), Functional Connectivity in Brain Networks Underlying Cognitive Control in Chronic Cannabis Users. Neuropsychopharmacology, 37: 1923 IF: 6.544, Citations: 72
  51. S Whittle, M Yücel, V Lorenzetti, ML Byrne, JG Simmons, SJ Wood, C Pantelis, N Allen (2012). Pituitary volume mediates the relationship between pubertal timing and depressive symptoms during adolescence. Psychoneuroendocrinology. 37: 881-891 IF: 4.731, Citations: 23
  52. N Solowij, M Yücel, V Lorenzetti, D Lubman (2011), Does Cannabis Cause Lasting Brain Damage? Marijuana and Madness, 2nd Edition, IX: 103-113. Citations: 5
  53. A Zipursky, S Whittle, M Yücel, V Lorenzetti, S Wood, D Lubman, J Simmons, N Allen (2011). Pituitary volume prospectively predicts internalizing symptoms in adolescence. Journal of Child Psychology and Psychiatry, 52: 315-323. IF: 6.486, Citations: 13
  54. V Lorenzetti, D Lubman, S Whittle, N Solowij, M Yücel (2010) Structural MRI findings in long-term cannabis users: What do we know? Substance Use and Misuse, 45:1787-1808. IF: 1.132, Citations: 93
  55. V Lorenzetti, D Lubman, D Velakoulis, M Yücel (2010). Pituitary gland volume among heroin users stabilised on substitution Pharmacotherapy. Drug and Alcohol Dependence, 110:164-166. IF: 3.322, Citations: 7
  56. T Takahashi, M Walterfang, SJ Wood, MJ Kempton, J Jogia, V Lorenzetti, B Soulsby, M Suzuki, D Velakoulis, C Pantelis, S Frangou (2010). Pituitary volume in patients with bipolar disorder and their first-degree relatives. Journal of Affective Disorders, 124: 256-261. IF: 3.786, Citations: 30
  57. T Takahashi, M Yücel, V Lorenzetti, M Walterfang, K Kawasaki, S Whittle, S Suzuki, C Pantelis, N Allen (2010). An MRI study of the superior temporal subregions in patients with current and past major depression. Progress in Neuro- Psychopharmacology & Biological Psychiatry, 34: 98-103. IF: 4.185, Citations: 36
  58. T Takahashi, M Yücel, V Lorenzetti, T Tanino, S Whittle, S Suzuki, M Walterfang, C Pantelis, N Allen (2010). Volumetric MRI study of the insular cortex in individuals with current and past major depression. Journal of Affective Disorders, 121: 231-238. IF: 3.786, Citations: 79
  59. N Solowij, M Yücel, V Lorenzetti, D Lubman (2009), Structural Brain Alterations in Cannabis Users: Association with Cognitive Deficits and Psychiatric Symptoms. The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers, III: 215-225. Citations: 5
  60. * V Lorenzetti, N Allen, S Whittle, M Yücel (2009), Amygdala volumes in a sample of current depressed and remitted depressed patients and healthy controls. Journal of Affective Disorders, 120: 112-119. IF: 3.786, Citations: 57
  61. M Walterfang, M Yücel, SB Barton, DR Reutens, AW Wood, JC Chen, V Lorenzetti, D Velakoulis, C Pantelis, N Allen (2009), Corpus callosum size and shape in individuals with current and past depression. Journal of Affective Disorders, 115: 411 &ndash 420. IF: 3.786, Citations: 36
  62. T Takahashi, M Malhi, S Wood, M Walterfang, M Yücel, V Lorenzetti, B Soulsby, S Suzuki, D Velakoulis, C Pantelis (2009), Increased pituitary volume in patients with established bipolar affective disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33: 1245-1249. IF: 4.185, Citations: 14
  63. T Takahashi, MS Suzuki, D Velakoulis, V Lorenzetti, B Soulsby, SZ Zhou, KN Nakamura, HS Seto, MK Kurachi, C Pantelis (2009), Increased pituitary volume in schizophrenia spectrum disorders. Schizophrenia Research, 108: 114-121. IF: 3.958, Citations: 43
  64. T Takahashi, M Yücel, V Lorenzetti, N Nakamura, S Whittle, M Walterfang, S Suzuki, C Pantelis, N Allen (2009), Midline brain structures in patients with current and remitted major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33: 1058-1063. IF: 4.185, Citations: 21
  65. V Lorenzetti, N Allen, A Fornito, C Pantelis, GD De Plato, A Ang, M Yücel (2009), Pituitary gland volume in currently depressed and remitted depressed patients. Psychiatry Research &ndash Neuroimaging, 172: 55-60. IF: 2.455, Citations: 15
  66. V Lorenzetti, N Allen, A Fornito, M Yücel (2009), Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies. Journal of Affective Disorders, 117:1-17 IF:3.786, Citations:414




Dr Lorenzetti's research focuses on mapping brain, cognitive and mental health outcomes in substance use and addiction using neuroimaging, multi-site studies and longitudinal neuroimaging consortia in adults and adolescents. She is also interested in unpacking which variables drive adverse brain, cognition and mental health outcomes in addiction, including recreational use versus dependence use, sex differences and drug potency and how such harms can be reduced with accessible evidence-based interventions (such as mindfulness, neurofeedback, cannabidiol administration). 

I regularly provided advanced training in neuroimaging methods and techniques to examine psychiatry disorders and neurodevelopment, involving to date >30 graduate/postgraduate students, and ~20 international visiting academics from national/international research centres. This work resulted in publications in peer-reviewed international journals and preparation for and Honors/PhD theses.

Professional Memberships

Assistant Editor, Addiction

Editorial Board, Psychiatric Research Neuroimaging

Member of:

European College of Neuropsychopharmacology

Society for the Study of Addiction

World Federation Society for Biological Psychiatry


ENIGMA Addiction consortium

Neuroscience Interest Group, Lead of Neuroimaging stream


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