Staff Directory

Dr Roger Lord Name: Dr Roger Lord
Lecturer (Medical Science)
Phone
+617 3623 7240
Organisational Area
Faculty of Health Sciences
Department
School of Behavioural and Health Sciences (QLD)
Location
Brisbane
Building 208 (1100 Nudgee Road, Banyo QLD 4014)-Level 2-Room 208.2.19
Biographical Information

Roger Lord, BAppSc (QUT), PhD (Dokkyo University Japan). I have worked in many different institutions during the course of my career which in turn is reflected in my publications record. My first post as a Research Assistant was as part of the Malaria Vaccine group based at the Queensland Institute of Medical Research (QIMR), Brisbane, Australia and involved the use of monoclonal antibody technology to map potential parasite antigens for use in a peptide based vaccine against Plasmodium falciparum.

 

After six years in this post (1986 – 1992), I joined the Joint Transplantation Biology Program (University of Queensland, Department of Surgery/QIMR, 1993 –1996) where I investigated mechanisms involved in liver allograft tolerance and during which time I completed my PhD studies via Dokkyo University in Japan.

 

I then moved to Cardiff, (United Kingdom) to join the University of Wales College of Medicine as a (BHF) Research Fellow to undertake post doctoral studies on the Patho-immunological mechanisms involved in dilated cardiomyopathy, autoimmune myocarditis and diabetic cardiomyopathy.

 

In 2000, having had enough of Cardiff’s inclement weather, I returned home to Australia to take up a lectureship with the Department of Surgery, University of Tasmania (UTAS). I was involved in teaching students from medicine, science and pharmacy while building a new research program centred on proteomics and set up the first such facility for this science in Tasmania in 2001.

 

The use of this instrumentation was then applied to differential analysis of breast tissue from women undergoing breast reduction surgery against cancerous tissue from consenting patients from Australia, Taiwan and Greece. Studies involving these resources are still on going today (collaboration with UTAS) and it is hoped that this approach will yield new diagnostics and possible vaccine approaches to treat breast cancer.

During 2006 I returned to Brisbane where I worked for 6 months on breast cancer immunotherapy at the Mater Medical Research Institute (MMRI) and these studies involved investigating tumour associate antigen for presentation to dendritic cells which in turn complimented the work being undertaken in Tasmania.

 

My desire to be involved in teaching again has led me back to this role and was a part of the School of Nursing, Midwifery & Paramedicine 2007- 2013, before joining the School of Science in 2014, Australian Catholic University (ACU) where I hope to contribute the education of health care professionals from the varied experiences I have had in my career to date. I also lecture to students under taking degrees in nursing, nursing/paramedicine, midwifery, physiotherapy, exercise science, public health, speech pathology & occupational health.

 

Ø   Qualifications:

 

Associate Diploma in Applied Science

(Major: Biology) awarded with distinction, Queensland Institute of Technology (QIT, now QUT), 1987.

 

Bachelor of Applied Science (B.App.Sc) (Major: Biology) (Submajors: Medical Microbiology/Biochemistry), Queensland University of Technology (QUT).

 

Doctor of Philosophy (Ph.D), Department of Surgery I, Dokkyo University School of Medicine (Japan), 1996 - My doctoral work centred on immunosuppressive proteins induced following liver transplantation. Experienced gained during my studies included advanced protein biochemistry, immunoassays for suppression and microsurgical techniques.

 

AWARDS:   1991 Young Queenslander of the Year (Malaria vaccine 

                             development).

                     1992 Young Achiever for Science & Technology (awarded by  

                              Dept of Business, Industry & regional development – State

                              Government).

                     1996 SANDOZ Young investigator award (Liver transplant 

                              biology).

 

Publications

Saul A, Lord R, Jones G, Geysen HM, Gale J, Mollard R. Crossreactivity of antibody against an epitope of the P. falciparum second merozoite surface antigen. Parasite Immunology, 11(6):593-601, (1989).

 

Kara U, Pye D, Lord R, Pam C, Gould H, Geysen M, Jones G, Stenzel D, Kidson C, Saul A. Immune response to a synthetic peptide corresponding to an epitope of a parasitophorus vacuole membrane antigen from P. falciparum. Journal of Immunology 143(4):1334-1339, (1989).

 

Ramasamy R, Jones G, Lord R. Characterisation of a unique epitope recognised by a monoclonal antibody against a 45 kDa P. falciparum merozoite surface antigen. Immunology Letters, 23:305-310, (1989).

 

Jones GL, Gale J, Lord R, Edmundson HM, Saul A. High titre response against a malarial antigen depends on the flanking sequence of the immunising peptide conjugate. Peptide Research, 2:282-286, (1989).

 

Lord R. Use of ethanol for euthanasia of mice. Australian Veterinary Journal, 66(8):268, (1989).

 

Lord R, Saul A. Adaptation of a Quackenbush hybridoma cell line to grow successfully in Balb/c mice. In Vitro Cell. Dev. Biol., 26:1028-1029, (1990).

 

Jones GL, Spencer L, Lord R, Mollard R, Pye D, Saul A. Peptide vaccines derived from a malarial surface antigen – Effects of dose and adjuvant on immunogenicity. Immunology Letters, 24:253-260, (1990).

 

Rzepczyk C, Csurhes P, Lord R, Matile H. Synthetic peptide immunogens eliciting antibodies to Plasmodium falciparum sporozoite and merozoite surface antigens in H-2b and H-2k mice. Journal of Immunology, 145:2691-2696, (1990).

 

Lord R, Jones GL, Spencer L. Ethanol euthanasia and its effect on the binding of antibody generated against an immunogenic peptide construct. Research in Veterinary Science, 51:164-168, (1991).

 

Lloyd-Jones G, Lord R, Spencer L, Saul A. Comparative immunogenicity of free and carrier-conjugated peptides derived from the constant regions of a polymorphic malarial surface antigen. Immunology Letters, 27:209-214, (1991).

 

Jones G, Edmundson H, Lord R, Spencer L, Mollard R, Saul A. Immunological fine structure of the variable and constant regions of a polymorphic malarial surface antigen from Plasmodium falciparum. Molecular and Biochemical Parasitology, 48:1-10, (1991).

 

Jones G, Spencer L, Lord R, Edmunson H, Saul A. High-titre antisera production using three adjuvants and peptide conjugates derived from malarial surface antigen MSA-2. Peptide Research, 4:138-141, (1991).

 

Saul A, Lord R, Jones GL, Spencer L. Protective immunization with invariant peptides of the Plasmodium falciparum antigen MSA2. Journal of Immunology, 148:208-211, (1992).

 

Lord R, Jones GL, Saul A. Two immunogenic peptide conjugates derived from P. falciparum MSA2 give rise to antibodies that crossreact with a nonhomologous 195 kDa malarial protein. Peptide Research, 6:191-194, (1993).

 

Lord R, Jones G, Spencer L, Saul A. Mice immunized with a synthetic peptide construct corresponding to an epitope present on a Plasmodium falciparum antigen are protected against Plasmodium chabaudi challenge. Parasite Immunology, 15:613-618, (1993).

 

Lord R, Jones GL, Saul A. The influence of water-miscible alcohols on the conformation of antibodies directed against a defined epitope. Peptide Research, 7:36-39, (1994).

 

Lord R, Goto S, Kobayashi E, Kamada N, Sunagawa M. Detection of membrane-bound and soluble MHC class I antigen from donor migrating cells following rat liver transplantation. Transplant Immunology, 2:94-98, (1994).

 

Kobayashi E, Kamada N, Enosawa S, Toyama N, Delriviere L, Goto S, Lord R, Stamatiou S, Miyata M. A technique for complete thymectomy in adult rats. Journal of Immunological Methods, 171:33-36, (1994).

 

Goto S, Kamada N, Moore T, Ware F, Lord R, Kobayashi E, Kim Y. The influence of intestinal congestion on survival of preserved liver grafts in rat liver transplantation. Transplantation, 58:974-977, (1994).

 

Goto S, Kamada N, Lord R, Kobayashi E, Enosawa S, Kim Y. Induction of natural chimerism after retransplantation  of the liver in rats. Transplantation, 58:1230-1235, (1994).

 

Kobayashi E, Kamada N, Delriviere L, Lord R, Goto S, Walker N, Enosawa A, Miyata M. Migration of donor cells into the thymus is not essential for induction and maintenance of systemic tolerance after liver transplantation in the rat. Immunology, 84:333-336, (1995).

 

Lord R, Kamada N, Kobayashi E, Goto S, Sunagawa M. Isolation of a 40 kDa immunoinhibitory protein induced by rat liver transplantation. Transplant Immunology, 3:174-179, (1995).

 

Goto S, Kamada N, Delriviere L, Kobayashi E, Lord R, Ware F, Hara Y, Edwards-Smith C, Shimizu Y, Vari F. Orthotopic liver retransplantation in rats. Microsurgery, 16:167-170, (1995).

 

Jones GL, Spencer L, Lord R, Edmundson H, Saul A. Effect of context and adjuvant on the immunogenicity of recombinant proteins and peptide conjugates derived from the polymorphic malarial surface antigen MSA2. Vaccine, 14:77-84, (1996).

 

Goto S, Lord R, Kobayashi E, Vari F, Edwards-Smith C, Kamada N. Novel immunosuppressive proteins purified from the serum of liver-retransplanted rats. Transplantation, 61:1147-1151, (1996).

 

Edwards-Smith C, Goto S, Lord R, Shimizu Y, Vari F, Kamada N. Allograft acceptance and rejection, mediated by a liver suppressor factor, LSF-1, purified from serum of liver transplanted rats. Transplant Immunology, 4:287-292, (1996).

 

Goto S, Shimizu Y, Lord R, Vari F, Edwards-Smith C, Chiba S, Kamada N. The beneficial effect of prostacyclin analog (OP2507) on liver transplantation subjected to an extended anhepatic phase in rats. Transplant International, 9:607-610, (1996).

 

Shimizu Y, Goto S, Lord R, Vari F, Edwards-Smith C, Chiba S, Schlect D, Buckley M, Kusano M, Kamada N. Liver passenger leukocytes can be reconstituted by splenic lymphocytes. Transplant International, 9:593-595, (1996).

 

Shimizu Y, Goto S, Lord R, Edwards-Smith C, Chiba S, Schlect D, Buckley M, Kusano M, Kamada N. The prevention of graft-versus-host disease by the serum of liver re-transplanted rats. Transplant Immunology, 5:67-69, (1997).

 

Lord R, Goto S, Vari F, Edwards-Smith C, Chiba S, Sunagawa M, Lynch SV. Differences in the rate of donor leucocyte migration between natural and drug-assisted tolerance following rat liver transplantation. Clinical and Experimental Immunology, 108:358-365, (1997).

 

Chiba S, Goto S, Shimizu Y, Vari F, Lord R, Edwards-Smith C, Kobayashi S, Ochiai T, Isono K. The characterisation of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation. Transplant International, 10:350-356, (1997).

 

Kobayashi S, Lord R, Goto S, Chiba S, Okumura K, Nagaoka I. Production of IL-2 by hepatocytes in allografted liver of rats. Transplant Immunology, 5:237-239, (1997).

 

Lord R, Vari F, Goto S, Sunagawa M. Antigen presenting cells and chimerism. Transplant Immunology, 6:61-63, (1998).

 

Kobayashi S, Goto S, Lord R, Shimizu Y, Swanson C, Vari F, Edwards-Smith, Chiba S, Pan TL, Chen CL. Analysis of immunosuppressive proteins in serum of liver transplanted rats using an anti-LSF-1 affinity column. Journal of Surgical Research, 80:58-61, (1998).

 

Goto S, Noguch T, Morotomi Y, Lord R, Board J, Chen CL, Jawan B, Pan TL, Chen YS, Tatsuma T, Kitano S, Lynch SV. A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation. Transplant Immunology 6:265-267, (1998).

 

Lord R, Goto S, Vari F, Long-Pan T, Chiang KC, Chen CL, Sunagawa M. Immunisation with a synthetic peptide conjugate derived from the N-terminal sequence of either the beta chain of haemoglobin or the immunosuppressive protein (reOLT 4) reduces the litter size of pregnant rats. Scandinavian Journal of Immunology, 49:162-168, (1999).

 

Pan TL, Goto S, Lin YC, Lord R, Chiang KC, Lai CY, Chen YS, Eng HL, Cheng YF, Tatsuma T, Kitano S, Lin CL, Chen CL. The Fas and Fas ligand pathways in liver allograft tolerance. Clinical and Experimental Immunology, 118:180-187, (1999).

 

Pan TL, Lin CL, Chen CL, Lin YC, Gojo S, Lee TH, Wang YH, Lord R, Lai CY, Tsu LW, Tseng HP, Wu ML, Iwashita Y, Kitano S, Chiang KC, Hashimoto T, Sugioka A, Goto S. Identification of the indoleamine 2,3-dioxygenase nucleotide sequence in a rat liver transplant model. Transplant Immunology, 8:189-194, (2000).

 

Chiang KC, Goto S, Chen CL, Lin CL, Lin YC, Pan TL, Lord R, Lai CY, Tseng HP, Hsu LW, Lee TH, Yokoyama H, Kunimatsu M, Chiang YC, Hashimoto T. Clusterin may be involved in rat liver allograft tolerance. Transplant Immunology, 8: 95-99, (2000).

 

Lord R, Goto S, Pan TL, Chiang KC, Chen CL, Sunagawa M. Peak protein expression of IL-2 and IFN-gamma correlate with the peak rejection episode in a spontaneously tolerant model of rat liver transplantation. Cytokine, 13:155-161, (2001).

 

Lin YC, Goto S, Pan TL, Hong YR, Lin CL, Lord R, Chiang KC, Lai CY, Tseng HP, Hsu LW, Iwashita S, Kitano S, Chen CL. Identification of two down-regulated genes in rat liver allografts by mRNA differential display. Transplant International, 14:153-158, (2001).

 

Cheng YF, Chen CL, Lai CY, ChenTY,Huang TL, Lee TY, Lin CL, Lord R, Chen YS, Eng HL, Pan TL, Lee TH, Wang YH, Iwashita Y, Kitano S, Goto S. Assessment of donor fatty livers for liver transplantation. Transplantation, 71:1221-1225, (2001).

 

Vari F, Lord R, Goto S. LSF-1 may modulate the indirect allorecognition pathway to delay allograft rejection. Transplant Immunology, 10:259-267, (2002).

 

El-Omar MM, Lord R, Draper NJ, Shah AM. Role of nitric oxide in posthypoxic contractile dysfunction of diabetic cardiomyopathy. The European Journal of Heart Failure, 5:229-239, (2003).

 

Hsu LW, Goto S, Lin YC, Lai CY, Tseng HP, Wu CI, Lord R, Kitano S, Chen SH, Chen CL. Prolongation of heart allograft survival of rats treated by a Th2 inhibitor. Transplant Immunology, 11:385-388, (2003).

 

Roberts KM, Bhatia K, Stanton P, Lord R. Proteomic analysis of selected prognostic factors of breast cancer. Proteomics, 4:784-792, (2004).

 

Hsu LW, Goto S, Nakano T, Lai CY, Kao YH, Lin YC, Kawamoto S, Ono K, Lord R, Goto T, Omori N, Sato S, Chiang KC, Chen SH, Jawan B, Cheng YF, Chiu KW, Chen CL. The effects of anti-histone H1 antibody on immune cells responsible for rejection reaction. Molecular Immunology, 42:1155-1164, (2005).

 

Luk PP, Sinha SN, Lord R. Upregulation of inducible nitric oxide synthase (iNOS) expression in faster-healing chronic leg ulcers. Journal of Wound Care, 14:373-381, (2005).

 

Jacobson GA, Featherstone AM, Townsend AT, Lord R, Peterson GM. Selenoprotein P analysis in human plasma. Journal of Biological Trace Element Research, 107:213-220, (2005).

 

Jacobson GA, Narkowicz C, Lord R, Howard BJ, Chung S. Effect of cyclooxygenase-2 expression and possible variants in a patient with Barrett’s esophagus. Diseases of the Esophagus, 20:265-268, (2007).

 

Scott DK, Lord R, Muller RC, Woods GM. Proteomics identifies enhanced expression of stefin A in neonatal murine skin compared with adults: functional implications. British Journal of Dermatology, 156:1156-1162, (2007).

 

Research

(1). Breast cancer angiogenesis and development of new diagnostics via the use of proteomics and bioinformatics. Have collected a library of breast tissue from consenting patients from three distinct cohorts for this purpose (Australia, Greece and Taiwan). In collaboration with the University of Tasmania and Royal Hobart Hospital, Australia and Chang Gung Memorial Hospital, Taiwan.

I am also interested in proteomics generally have acted as a consultant for both internal and external groups applying this science to various research questions.

(2). Transplantation biology � mechanisms involved in allograft tolerance/rejection with special reference to the liver, in collaboration with investigators in Japan. Liver transplantation tolerance was the subject of my doctoral dissertation.

(3). Immunological mechanisms involved in accelerating healing of chronic wounds with special reference to leg ulcers. The role of nitric oxide donors in this process and effect on bacterial flora. The use of pro-biotic therapy for treatment chronic wounds and wound healing in general.

(4). Vaccine formulation (peptide chemistry) and development of reagents against Plasmodium species (malaria) and relationship with erythrocyte biology.

(5). Examination of salivary IgA levels in elite AFL players as a measure of stress/recovery. This is been done in conjunction with the Schools of Physiotherapy & Exercise Science at ACU.

NB: Projects exist for postgraduate study in Nursing, Midwifery & Exercise Science. Please contact me if you would like further information.

Experience

 

Honours Course Advisor - Nursing, Midwifery & Paramedicine 2012

Lecturer in Charge (Brisbane Campus) - School of Nursing, Midwifery & Paramedicine

Applied Science for Practice 3 (BIOL 228) - 2007

Applied Science for Practice 4 (BIOL 229) - 2007, 2008, 2009

Applied Science for Practice 5 (BIOL 326) - 2008, 2009, 2010

Foundation Biological Science 2 (BIOL 120) - 2010

Interpreting and Applying Evidence (HLSC601) - 2012

Lecturer in Charge (Brisbane Campus) - School of Science

Human Biological Science One and Two (BIOL121 & BIOL122) - 2014

Professional Memberships


Member Australian Society for Biochemistry and Molecular Biology (ASBMB)

Member Australasian Wound & Tissue Repair Society

Member Australian Wound Management Association

Associate of the Royal College of Pathologists of Australasia

Member of BUNSE (Brisbane Universities Network of Science Educators)

Friends of the International Union of Biochemistry and Molecular Biology

 

Have a question?

askacu

We're available 9am–5pm AEDT,
Monday to Friday

If you’ve got a question, our AskACU team has you covered. You can search FAQs, text us, email, live chat, call – whatever works for you.

Live chat with us now

Chat to our team for real-time
answers to your questions.

Launch live chat
Visit our FAQs page

Find answers to some commonly
asked questions.

See our FAQs