Dr David Good
I have worked in the field of biomedical research since commencing post-graduate studies in 1997. Since then I have been involved in a number of different internationally recognised research projects ranging from obesity to cancer. In 2008 helped I established the Division of Molecular and Gene Therapies within the Griffith Institute for Health and Medical Research. I was subsequently appointed the Head of the Clinical Research Unit. Some of the projects I am currently involved in include, genetics of type 2 diabetes, research into solid tumours (lung cancer, prostate, breast and colorectal cancer) and Chinese traditional medicines. In early 2009, I help establish a collaborative link with the Guangdong Pharmaceutical University in Guangdong Province China and more recently I have been responsible for establishing links with an industry partners.
Over the course of my career I have had the opportunity to teach medical students at the University of Queensland. Since 2008 I was the course convenor (lecturer-in-charge) for anatomy and physiology at Griffith University. In this role I received many student nominations for Teaching Excellence Awards. In 2010, I also received a Commendation for outstanding performance in enhancing the quality of student learning.
PhD: Griffith University, Brisbane, Australia. Research component undertaken at the Princess Alexandra Hospital, Department of Diabetes and Endocrinology, Brisbane, Australia.
First Class Honours: Griffith University, Brisbane, Australia. Research component undertaken at the CSIRO Division of Tropical Agriculture, Brisbane Australia.
Bachelor of Science: Griffith University, Brisbane, Australia.
Publications in preparation or under review
Chun Li, David A Good, Albert S Mellick, Ming Q Wei. Apoptosis and microRNA Aberrations in Cancer. [review article]
Good DA, Duffy DL, Cardinal J, Good M, Guo CX, Busfield F, Chan LCK, Shaw JTE. The identification of a novel gene responsible for type 2 diabetes in an Indigenous Australian population.
Good DA, Lovelock PK, Busfield F, Walker S, Guo C, Kesting JB, Duffy DL, Shaw JTE. A genome-wide search for type 2 diabetes susceptibility loci in an Australian family of mixed Pacific Islander/European descent.
Chan LCK, Ware RS, Kesting J, Marczak M, Good D, Shaw JTE. Efficacy of a lifestyle intervention program on cardiovascular health outcome in overweight Indigenous Australians with and without type 2 diabetes mellitus over 2 years: The Healthy Lifestyle Program (HELP).
Chan LCK, Ware RS, Guo CX, Kesting JB, Good D, Shaw JTE. Relationship between apolipoprotein E4 genotype, dyslipidaemia and plasma C-reactive protein levels in Indigenous Australians.
Chan LCK, Ware RS, Kesting J, Marczak M, Good D, Shaw JTE. High sensitivity C-reactive protein levels and cardiovascular risk factors in a high risk group of Indigenous Australians.
Chan LCK, Guo CX, Kesting JB, Good DA, Shaw JTE. Characterisation of C-reactive protein gene polymorphisms and plasma c-reactive protein levels in Indigenous Australians.
Publications in Refereed Journals
Xie J, Cao S, Good DA, Wei M, Ren X. A Combination of Fluorescent Dye and Zn-S Nanocluster and Its Biological Application on Stain Bacteria. Inorg Chem. 2010 Feb 15;49(4):1319-21.
Qin Yao, Xun Qu, Qifeng Yang, D. Good, Shuzhen Dai, Beihua Kong and M. Wei. Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models. Molecular Cancer. 2009; vol.8, no.78.
Weijian Bei, Xinghong Zhu, M. Wei, Chuyuan Li, Linquan Zang, Jiao Guo, Wenlie Peng, Anlong Xu, D. Good, Yinming Hu, Wei Wu and Dehui Hu. Neuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves. Journal of Ethnopharmacology. 2009; vol.126.
Wei MQ, Ren A, Good D and Anne J. “Trojan horse” vectors based on anaerobic bacteria for cancer gene therapy. Gene Vaccine & Therapy. 2008; 6:8
Wei MQ, Mengesha A, Good D, Anné J. Bacterial targeted tumour therapy – dawn of a new era. Cancer Letters. 2008; 259:16 – 27.
Wei MQ, Ruimei R, Good D, Anné J. Clostridial spores as live ‘Trojan horse’ vectors for cancer gene therapy: comparison with viral delivery systems. Genetic Vavvines and Therapy. 2008; 6:8
D. Good, John Cardinal, Robert S Ware, Lisa Marks, Janine B Kesting, Lionel CK Chan, Joanne TE Shaw. Susceptibility to insulin resistance in indigenous Australians may be down stream of resistin. International Journal of Diabetes and Metabolism. 2008 16: 1-6 .
Chan LCK, Ware R, Kesting J, Marczak M, Good D, Shaw JTE. Association between anthropometric measures of obesity and cardiovascular risk markers in a self-selected group of Indigenous Australians. European Journal of Cardiovascular Prevention and Rehabilitation 2007; 14(4):515-7.
Chan LCK, Ware R, Kesting J, Marczak M, Good D, Shaw JTE. Short term efficacy of a lifestyle intervention programme on cardiovascular health outcome in overweight Indigenous Australians with and without type 2 diabetes mellitus - The Healthy Lifestyle Programme (HELP). Diabetes Research and Clinical Practice 2007; 75:65-71
Chan LC, Ware RS, Kesting J, Marczak M, Good D, Shaw JT. Association between anthropometric measures of obesity and insulin resistance in a self-selected group of Indigenous Australians. Heart, Lung and Circulation. 2007; 16(4):303-4.
Mukhopadhyay S, Good DA, Miller RD, Graham JE, Mathews SA, Timms P and Summersgill JT. (2006) Identification of chlamydia pneumoniae proteins in the transition from reticulate to elementary body formation. Molecular and Cellular Proteomics. 2006 Dec; 5(12):2311-2318.
Shaw JTE, Chan LCK, Good D. Maturity onset diabetes of the young. Diabetes Management 2006; 15:7 (review)
Good DA, Busfield F, Fletcher B, Lovelock PK, Duffy D, Kesting J, Andersen J, Shaw J.T.E. Identification of SQSTM1/p62 mutations in familial Paget’s disease in Australian pedigrees. Bone. 2004 Jul;35(1):277 - 282
Good DA, Busfield F, Fletcher BH, Duffy DL, Kesting JB, Andersen J, Shaw JT. Linkage of Paget’s disease of bone to a novel region on human chromosome 18q23. American Journal of Human Genetics. 2002 Feb; 70(2):517-25.
Busfield F, Duffy DL, Kesting JB, Walker SM, Lovelock PK, Good D, Tate H, Watego D, Marczak M, Hayman N, Shaw JT. A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians. American Journal of Human Genetics. 2002 Feb; 70(2):349-57.
Good D, Busfield F, Duffy D, Lovelock PK, Kesting JB, Cameron DP, Shaw JT. Familial Paget's disease of bone: nonlinkage to the PDB1 and PDB2 loci on chromosomes 6p and 18q in a large pedigree. Journal of Bone Mineral Research. 2001 Jan; 16(1):33-8.
I have worked on a number of health related research topics that have covered many different clinical conditions and biological systems. These topics have included obesity, Paget’s disease of bone, the implication of Chlamydia pneumoniae infection in the etiology of atherosclerosis, hypertension, solid tumours and type 2 diabetes in both a community based education program as well as a laboratory based project.
My current research projects at Division of Molecular and Gene Therapies include trying to produce more effective safer treatments for solid tumours. Solid tumours account for 90% of all cancers and gene therapy represents a potential new modality for their treatment.
Previous research projects include:
1) The genetics of type 2 diabetes in an Indigenous Australian community. In this project we have been searching for genes responsible for type 2 diabetes. In this project I was successful in the identification of a novel gene responsible for this condition. In this project we has also looked at both current and emerging biochemical markers for both type 2 diabetes and cardiovascular diseases and looked at any correlation with either molecular markers or disease state.
2) Along with the genetic work in the Indigenous Australian community, we implemented a lifestyle intervention program in order to educate these people on how to manage their diabetes, decrease their weight and subsequently reduce the burden of type 2 diabetes. We have also assayed a number of important biochemical markers for cardiovascular disease and studied the correlation between them and molecular markers or disease state.
Page last updated: 2018-01-22
Short url: https://www.acu.edu.au/1273347